Salivary L-fucose as a biomarker for oral potentially malignant disorders and oral cancer

Background: The objective of this study was to evaluate the serum and salivary L-fucose in oral potentially malignant disorders (OPMDs) and oral cancer (OC) in order to investigate the possibility of using this as biomarker for early diagnosis. Materials and Methods: The study included 85 participants, who were grouped as control (30), OPMDs patients (25), and OC patients (30). Serum and unstimulated whole saliva were collected from participants of all groups and fucose estimation was done using spectrophotometry. The results were tabulated and analyzed statistically. Results: The mean serum L-fucose levels in normal, OPMDs, and OC group were 3.49, 19.18, and 35.75 mg/dl, respectively, while the levels of salivary L-fucose were 3.18, 7.02, and 11.66 mg/dl, respectively. A highly significant rise (P < 0.001) in serum and salivary L-fucose was observed in the study participants compared to control. Conclusions: The present study showed a significant and gradual increase in serum and salivary L-fucose from control to OPMDs to OC. From this study, we suggest that L-fucose can be used as a reliable biomarker and saliva can be used as a diagnostic fluid for screening and early detection of OC

Bilateral fusion in primary mandibular teeth.

Fusion has been described as a developmental anomaly characterized by the union of two adjacent teeth. Few cases of this rare anomaly in primary dentition have been reported in Indian population. A rare case of bilateral fusion between primary mandibular lateral incisors and canines is presented in this report.

The effect of 0.5% sodium hypochlorite and 2% glutaraldehyde spray disenfectants on irreversible hydrocolloid impression material.

Infection control has assumed prime importance in dentistry. It is a prime concern in prosthodontics as well, where impressions materials are most commonly used. Impression materials can act as a medium for cross infection. To prevent cross infection many products are being developed. Among them 0.5% Sodium hypochlorite and 2% Glutaraldehyde are considered effective. This study was done to asses the efficacy of 0.5% Sodium hypochlorite and 2% Glutaraldehyde on irreversible hydrocolloid impression material. The result of the study indicated that they are effective against both Gram positive and Gram negative organisms and their use is recommended.